I have a script that I use in the HTML inserts header area, similar to this layout:

<script type="text/javascript">
<!--
if {
;
}
//-->
</script>

Is there a way to restrict this script to the home page only? That is, I don't want it to run on any of the other pages on the site, just the home page.

have the jscript determine what page you are on and wrap your IF in an IF testing the page.

I would do some google searches on finding out how to do that if I were you.